Our Research Focuses...


... primarily on understanding the structure of motor proteins in the cell. We use Cryo Electron Microscopy to study microtubule-bound kinesin motors or actin-bound myosin motors. We use single particle 2D class averaging, in concert with novel computational methods developed by Chuck Sindelar to reveal the unique conformational changes undergone by these proteins.


We have recently branched out to collaborate with another lab to study the structure of the Leptospira flagella using Cryo Electron Tomography.



© 2015 by Charles Sindelar