Welcome to the Sindelar Lab!
We're a research lab in the Yale Department of Molecular Biophysics and Biochemistry (MB&B).
We use Cryo electron microscopy to study the structure and motion of motor proteins in the cell. Our main areas of focus lie in looking at how kinesin moves along microtubules and how myosin moves along actin filaments. We are also looking at how the AAA-ATPase, Spastin binds to microtubules and severs them into smaller pieces.
We are also using cryo-electron tomography and subvolume averaging to resolve the rather unique flagella filament from Leptospira spp., a Spirochaete bacteria that is the causitive agent in the tropical zoonotic disease, Leptospirosis.
333 Cedar Street
New Haven, CT 06520-8024